Journal article
Investigation of IRGANOX®1076 as a dosimeter for clinical X-ray, electron and proton beams and its EPR angular response
CL Smith, E Ankers, SP Best, F Gagliardi, K Katahira, Y Tsunei, T Tominaga, M Geso
Radiation Physics and Chemistry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
The suitability of IRGANOX®1076 in paraffin wax as a near-tissue equivalent radiation dosimeter was investigated for various radiotherapy beam types; kV and MV X-rays, electrons and protons over clinically-relevant doses (2 −20 Gy). The radical formed upon exposure to ionising radiations was measured by Electron Paramagnetic Resonance (EPR) spectroscopy, and the single peak signal obtained for solid solutions of IRGANOX®1076 in wax is attributed to the phenoxyl radical obtained by net loss of H•. Irradiation of solid IRGANOX®1076 gives a doublet consistent with the formation of the phenol cation radical, obtained by electron loss. Solid solutions of IRGANOX®1076 in paraffin wax give a linear..
View full abstractGrants
Awarded by Australian Research Council
Funding Acknowledgements
We wish to thank the School of Health and Biomedical Sciences at RMIT University for the financial support especially the funding to cover travel between Australia and Japan for access to the proton beam facility, Ms Sioe See Volaric for her expert assistance with EPR measurements at the University of Melbourne and Mr Robert Brown for use of the histology laboratory and paraffin wax. Also, we would like to acknowledge the support for this project by the staff of the Hyogo Ion Beam Centre in Japan, and the William Buckland Radiotherapy Centre in Australia. The ARC (linkage grant LE0775660), together with the School of Chemistry University of Melbourne, are thanked for the purchase and establishment of the EPR spectrometer and finally, thanks to Mr Neil Brouwer for making the silica moulds.